We are a group of geneticists, neuroscientists, and computer scientists who are passionate about discoveries of novel targets and models for mental illness through innovation at the confluence of computational, genetic, and genomic methods.
The Kumar Laboratory is located at the Jackson Laboratory in Bar Harbor, Maine. We study neural circuits in the brain whose misregulation leads to behavioral abnormalities including addiction, attention deficit and hyperactivity disorder, and depression. Using mouse molecular genetics as a foundation, and a combination of biochemistry, physiology, and imaging techniques we dissect these complex behaviors in mammals.
We use two functional genomics approaches in mice – forward genetic ethylnitrosourea (ENU) mutagenesis screens and quantitative trait loci (QTL) analysis – to identify genes and pathways that regulate these behaviors. Powerful and unbiased, forward genetic approaches make no a priori assumptions and only require a clear well-defined assay for gene discovery. We have used high-throughput screening pipeline to discover mutants for cocaine response and open field behavior. Using physical mapping followed by next generation sequencing we have identified novel genes and alleles that regulate cocaine response and anxiety related behaviors.
Latest Lab News:
Brian's paper on robust mouse tracking is published. This paper describes how to track mice in complicated environments. Sean and others contributed to this paper. https://doi.org/10.1038/s42003-019-0362-1 Data from the paper is here. [button...read more
Vivek spoke about addiction genetics and neuroscience to high schools students from across the state of Maine. Over 200 students competed in over a dozen categories in this year's science fair. More information about the event is here. Arojit Mitra was a...read more
Vivek presents the keynote address at the Maine Engineering Expo. Approximately 150 people attended the banquet. National Engineers Week was initiated to publicly promote the work and contributions of our nation's engineers. During this week, engineering professionals...read more
Visual examples of some of the compression tests. Original sub-panel of video and differences between original and compressed frames. Difference previews are amplified 2x to enhance visibility. Video Acquisition Imaging Hardware All data was acquired using the same...read more