The Kumar Laboratory is located at the Jackson Laboratory in Bar Harbor, Maine. We study neural circuits in the brain whose misregulation leads to behavioral abnormalities including addiction, attention deficit and hyperactivity disorder, and depression. Using mouse molecular genetics as foundation, and a combination of biochemistry, physiology, and imaging techniques we dissect these complex behaviors in mammals.
We use two functional genomics approaches in mice – forward genetic ethylnitrosourea (ENU) mutagenesis screens and quantitative trait loci (QTL) analysis – to identify genes and pathways that regulate these behaviors. Powerful and unbiased, forward genetic approaches make no a priori assumptions and only require a clear well-defined assay for gene discovery. We have used high-throughput screening pipeline to discover mutants for cocaine response and open field behavior. Using physical mapping followed by next generation sequencing we have identified novel genes and alleles that regulate cocaine response and anxiety related behaviors.
Latest Lab News:
Vivek presents poster at Gordon Research Conference on the Neurobiology of Addiction
Vivek attended the GRC on addiction at Newry, Maine. The conference consisted of ~200 neuroscientists.
Yehya passes their qualifying exam.
Yehya passed their quals in June 2022. Congratulations on becoming an official PhD candidate.
Kumar Lab organizes a symposium on Machine Learning and Behavior Quantification at IBANGS
The International Brain and Neural Genetics Society organized its 23rd Annual Genes, Brain & Behavior Meeting on May 23rd-27th, 2022 in Memphis at the UTHSC. The meeting was hybrid with over 100 participants. Vivek organized a symposium titled Behavior...