The Kumar Laboratory is located at the Jackson Laboratory in Bar Harbor, Maine. We study neural circuits in the brain whose misregulation leads to behavioral abnormalities including addiction, attention deficit and hyperactivity disorder, and depression. Using mouse molecular genetics as foundation, and a combination of biochemistry, physiology, and imaging techniques we dissect these complex behaviors in mammals.
We use two functional genomics approaches in mice – forward genetic ethylnitrosourea (ENU) mutagenesis screens and quantitative trait loci (QTL) analysis – to identify genes and pathways that regulate these behaviors. Powerful and unbiased, forward genetic approaches make no a priori assumptions and only require a clear well-defined assay for gene discovery. We have used high-throughput screening pipeline to discover mutants for cocaine response and open field behavior. Using physical mapping followed by next generation sequencing we have identified novel genes and alleles that regulate cocaine response and anxiety related behaviors.
Latest Lab News:
Visual examples of some of the compression tests. Original sub-panel of video and differences between original and compressed frames. Difference previews are amplified 2x to enhance visibility. Video Acquisition Imaging Hardware All data was acquired using the same...read more
The lab celebrated the end of the school year with a lunch at Side Street Cafe. Congratulations to Kai, who is off to Stanford in the fall. Congratulations to Alden, who is off to University of Massachusetts, Amherst in the fall. A big thanks to Megan McOsker from...read more
In this piece in the Ellsworth American, Vivek discussed what leads to opioid overdose and why those in recovery are at greater risk of...read more