We are a group of geneticists, neuroscientists, and computer scientists who are passionate about discoveries of novel targets and models for mental illness through innovation at the confluence of computational, genetic, and genomic methods.
The Kumar Laboratory is located at the Jackson Laboratory in Bar Harbor, Maine. We study neural circuits in the brain whose misregulation leads to behavioral abnormalities including addiction, attention deficit hyperactivity disorder, and depression. Using mouse molecular genetics as a foundation, and a combination of computational, biochemistry, physiology, and imaging techniques, we dissect these complex conditions in mammals.
Primarily, we use functional genomic approaches in mice to identify genes and pathways that regulate these behaviors. We seek to develop better models of human diseases that can be used by the biomedical research community for therapeutics. Recently, we have applied machine learning and artificial intelligence methods to understand animal behavior at high spatial and temporal resolution, objectively, and over long periods of time. Our work has been published in numerous high impact journals such as Science, eLife, Nature Communications Biology, among others.
Latest Lab News and Blogs:
Leinani's and Gautam's paper is online as a preprint. It is currently under review at Nature Aging.
Visual determination of sleep states is accepted in the journal Sleep. Congratulations to Brian and Mandy for leading this effort.
We received two new grants. The press release is here. We are looking for additional lab members. https://www.jax.org/news-and-insights/2021/september/untangling-the-biology-of-addiction
Very well written summary of our work in eLife. https://elifesciences.org/digests/63207/lights-camera-action
An updated version of Gait analysis paper is on Biorxiv. https://www.biorxiv.org/content/10.1101/2020.12.29.424780v2 It has new analysis from Keith Sheppard and Gautam Sabnis including several new figures in the supplement. We look forward to getting reviews...
Paper link is here https://elifesciences.org/articles/63207 Data associated with the paper is here with video data uploaded to Zenodo https://zenodo.org/record/4646088 We also share some videos of our network in action:...