We are a group of geneticists, neuroscientists, and computer scientists who are passionate about discoveries of novel targets and models for mental illness through innovation at the confluence of computational, genetic, and genomic methods.
The Kumar Laboratory is located at the Jackson Laboratory in Bar Harbor, Maine. We study neural circuits in the brain whose misregulation leads to behavioral abnormalities including addiction, attention deficit hyperactivity disorder, and depression. Using mouse molecular genetics as a foundation, and a combination of computational, biochemistry, physiology, and imaging techniques, we dissect these complex conditions in mammals.
Primarily, we use functional genomic approaches in mice to identify genes and pathways that regulate these behaviors. We seek to develop better models of human diseases that can be used by the biomedical research community for therapeutics. Recently, we have applied machine learning and artificial intelligence methods to understand animal behavior at high spatial and temporal resolution, objectively, and over long periods of time. Our work has been published in numerous high impact journals such as Science, eLife, Nature Communications Biology, among others.
Latest Lab News and Blogs:
The article can be found here. Standard link (you may share this link anywhere): https://academic.oup.com/sleep/advance-article-abstract/doi/10.1093/sleep/zsab260/6414386 Free-access link (see below for how you may use this link):...
Vivek was a co-organizer of the Impacts of Sleep and Circadian Biology on Alzheimer's Disease and Aging from Oct 16-22, 2021 at Highseas Conference Center. The short course had 25 residential students and over 100 virtual students. The instructors included leaders in...
The mouse gait paper has been accepted. A preprint is here - the final version will be shorter due to space limitations from the Journal. Congratulations to Keith and Gautam on leading this effort. The work was started by Justin Gardin, a stellar postdoc in the lab....
Leinani's and Gautam's paper is online as a preprint. It is currently under review at Nature Aging.
Visual determination of sleep states is accepted in the journal Sleep. Congratulations to Brian and Mandy for leading this effort.
We received two new grants. The press release is here. We are looking for additional lab members. https://www.jax.org/news-and-insights/2021/september/untangling-the-biology-of-addiction