Welcome

We are a group of geneticists, neuroscientists, and computer scientists who are passionate about discoveries of novel targets and models for mental illness through innovation at the confluence of computational, genetic, and genomic methods.

The Kumar Laboratory is located at the Jackson Laboratory in Bar Harbor, Maine. We study neural circuits in the brain whose misregulation leads to behavioral abnormalities including addiction, attention deficit and hyperactivity disorder, and depression. Using mouse molecular genetics as a foundation, and a combination of biochemistry, physiology, and imaging techniques we dissect these complex behaviors in mammals.

We use two functional genomics approaches in mice – forward genetic ethylnitrosourea (ENU) mutagenesis screens and quantitative trait loci (QTL) analysis – to identify genes and pathways that regulate these behaviors. Powerful and unbiased, forward genetic approaches make no a priori assumptions and only require a clear well-defined assay for gene discovery. We have used high-throughput screening pipeline to discover mutants for cocaine response and open field behavior. Using physical mapping followed by next generation sequencing we have identified novel genes and alleles that regulate cocaine response and anxiety related behaviors.


 

 

 

Latest Lab News:

Singularity Container Efficiency Benchmark

Singularity is a relatively new tool that extends docker-style containerized compute into the hands of researchers on compute clusters. For security reasons, most compute clusters did not allow docker containers, and would require any software to be installed by...

read more
Vivek attends the 2020 NIDA genetics consortium meeting

Vivek attends the 2020 NIDA genetics consortium meeting

Vivek and Arojit attended the NIDA genetics meeting in Bethesda, MD. They presented two posters. Vivek presented our work on cloning of a mutation that regulates cocaine responses. This is a new gene that has not been linked to cocaine responses.  Abstract from the...

read more
Vivek gives lecture at Dartmouth

Vivek gives lecture at Dartmouth

Vivek was invited to give a seminar at Dartmouth University by Dr. Gio Bosco and his postdoctoral fellow Shiva Sathyanarayana. Vivek spoke about the lab's work on Cyfip2 (work of postdoctoral Arojit Mitra, Kyungin Kim, and others). He also spoke about the lab's...

read more
Skip to toolbar