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Welcome

We are a group of geneticists, neuroscientists, and computer scientists who are passionate about discoveries of novel targets and models for mental illness through innovation at the confluence of computational, genetic, and genomic methods.

The Kumar Laboratory is located at the Jackson Laboratory in Bar Harbor, Maine. We study neural circuits in the brain whose misregulation leads to behavioral abnormalities including addiction, attention deficit and hyperactivity disorder, and depression. Using mouse molecular genetics as a foundation, and a combination of biochemistry, physiology, and imaging techniques we dissect these complex behaviors in mammals.

We use two functional genomics approaches in mice – forward genetic ethylnitrosourea (ENU) mutagenesis screens and quantitative trait loci (QTL) analysis – to identify genes and pathways that regulate these behaviors. Powerful and unbiased, forward genetic approaches make no a priori assumptions and only require a clear well-defined assay for gene discovery. We have used high-throughput screening pipeline to discover mutants for cocaine response and open field behavior. Using physical mapping followed by next generation sequencing we have identified novel genes and alleles that regulate cocaine response and anxiety related behaviors.


 

 

 

Latest Lab News and Blogs:

HE Plots at a glance

Multivariate response data are routinely generated from experiments carried out in our lab. For example, several interrelated gait metrics such as stride length, step length, limb duty factor etc. are extracted from each stride of the mouse. The goal is to gain...

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Opinion – Collaboration without collaborators

Recently, I got a golden opportunity to be at NIDA headquarters attending a meeting where leading scientists in the field of addiction were discussing the face validity of different behavioral assays on animal models to study aspects of human addiction. The discussion...

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Circadian and Sleep Research Support by NIH

Circadian and Sleep Research Support by NIH

I was part of a special emphasis study section last week titled - "Circadian Patterns of Gene Expression Associated with Disease" for RFA-HL-20-016. The RFA was sponsored by NHLBI and NIDA, so most of the proposals revolved around priorities of these two ICs.  Program...

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Transitioning from college to the lab

I finished my last semester of college pulling 3 AM thesis-writing sessions at the only restaurant that stayed open that late, chugging black teas and occasionally doing aerobics outside, making the other patrons uncomfortable. After turning in 98 pages of ramblings...

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Singularity Container Efficiency Benchmark

Singularity is a relatively new tool that extends docker-style containerized compute into the hands of researchers on compute clusters. For security reasons, most compute clusters did not allow docker containers, and would require any software to be installed by...

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Vivek attends the 2020 NIDA genetics consortium meeting

Vivek attends the 2020 NIDA genetics consortium meeting

Vivek and Arojit attended the NIDA genetics meeting in Bethesda, MD. They presented two posters. Vivek presented our work on cloning of a mutation that regulates cocaine responses. This is a new gene that has not been linked to cocaine responses.  Abstract from the...

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