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Welcome

We are a group of geneticists, neuroscientists, and computer scientists who are passionate about discoveries of novel targets and models for mental illness through innovation at the confluence of computational, genetic, and genomic methods.

The Kumar Laboratory is located at the Jackson Laboratory in Bar Harbor, Maine. We study neural circuits in the brain whose misregulation leads to behavioral abnormalities including addiction, attention deficit and hyperactivity disorder, and depression. Using mouse molecular genetics as a foundation, and a combination of biochemistry, physiology, and imaging techniques we dissect these complex behaviors in mammals.

We use two functional genomics approaches in mice – forward genetic ethylnitrosourea (ENU) mutagenesis screens and quantitative trait loci (QTL) analysis – to identify genes and pathways that regulate these behaviors. Powerful and unbiased, forward genetic approaches make no a priori assumptions and only require a clear well-defined assay for gene discovery. We have used high-throughput screening pipeline to discover mutants for cocaine response and open field behavior. Using physical mapping followed by next generation sequencing we have identified novel genes and alleles that regulate cocaine response and anxiety related behaviors.


 

 

 

Latest Lab News and Blogs:

Science during social isolation

One of the things that have been consistent in my life for the last 3 years, is my personality type INFP (Introvert--Sensing-Feeling-Perceiving) in the Myers-Briggs test. Thanks to an annual workshop organized by our institution around leadership skills that made me...

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Random Forests

Random Forests

The biggest perk of working at JAX besides getting to work in a team on exciting research problems is its location. The lab is situated between the Gulf of Maine and the mountains of Acadia National Park. The park offers innumerable outdoor activities. One such...

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Owning a reptile in a canine and feline companion world

Owning a reptile in a canine and feline companion world

Earlier this year, I decided to obtain a new addition to my home: a pet bearded dragon (Pogona vitticeps). It's been awhile since I've wanted a pet and finally made the move. While most people think that the pets of choice in america is either a cat or a dog, most...

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Kumar Lab receives a new grant from NIDA

Kumar Lab receives a new grant from NIDA

The Kumar Lab received a grant from NIDA to build new models of addiction. The press release is here https://www.jax.org/news-and-insights/2020/july/building-better-mouse-models-for-addiction-research The project summary is available here: PROJECT SUMMARY Addiction is...

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Kumar Lab hosts Dr. Eric Yttri for a virtual visit

Kumar Lab hosts Dr. Eric Yttri for a virtual visit

Dr. Yttri, from Carnegie Mellon University, Department of Biological Sciences, presented his lab's latest work from this paper. The paper uses unsupervised learning to understand the types of behaviors mice carry out. Dr. Yttri met with postdocs, engineers, and...

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PyTorch: keep the GPU busy

We all know it's important to use GPU resources efficiently, especially during inference. One easy and highly effective way to achieve this is to reorder some of your inference logic to exploit PyTorch's asynchronous GPU operations. This becomes especially important...

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