We are a group of geneticists, neuroscientists, and computer scientists who are passionate about discoveries of novel targets and models for mental illness through innovation at the confluence of computational, genetic, and genomic methods.
The Kumar Laboratory is located at the Jackson Laboratory in Bar Harbor, Maine. We study neural circuits in the brain whose misregulation leads to behavioral abnormalities including addiction, attention deficit hyperactivity disorder, and depression. Using mouse molecular genetics as a foundation, and a combination of computational, biochemistry, physiology, and imaging techniques, we dissect these complex conditions in mammals.
Primarily, we use functional genomic approaches in mice to identify genes and pathways that regulate these behaviors. We seek to develop better models of human diseases that can be used by the biomedical research community for therapeutics. Recently, we have applied machine learning and artificial intelligence methods to understand animal behavior at high spatial and temporal resolution, objectively, and over long periods of time. Our work has been published in numerous high impact journals such as Science, eLife, Nature Communications Biology, among others.
Latest Lab News and Blogs:
Jaycee and Vivek published a commentary entitled, A new era in quantification of animal social behaviors, in the Journal of Neuroscience & Biobehavioral Reviews. Link to article: https://pubmed.ncbi.nlm.nih.gov/38160721/
Vivek directs year 3 of the Short Course on the Impacts of Sleep and Circadian Biology on Alzheimer’s Disease and Aging
Year 3 of the R13 course was a success! Thank you to all who attended. https://www.jax.org/education-and-learning/education-calendar/2023/10-October/impacts-of-sleep-and-circadian-biology-on-alzheimers-disease-and-aging 2023_CC_Impacts of Sleep flyer v4...
The second year of the course was a success. We had 20+ instructors and ~35 students attend the course from all over the world! Lots of good science and hiking. JC, Jake, and Anshul attended the course from the Kumar Lab. JC was also a TA with Brian....
Our work on advanced phenotyping was mentioned in a news article in Nature. d41586-023-01926-w (1)
Our group photo for the summer of 2023!
Gautam, Brian, Jaycee, and Vivek gave oral presentations of their work at this year's CTC meeting in a session called "Machine learning for rodent behavior". https://complextrait.org/meetings/ctc-rg2023/program.html Talk Titles: A machine-vision-based frailty index...