The Kumar Laboratory is located at the Jackson Laboratory in Bar Harbor, Maine. We study neural circuits in the brain whose misregulation leads to behavioral abnormalities including addiction, attention deficit and hyperactivity disorder, and depression. Using mouse molecular genetics as foundation, and a combination of biochemistry, physiology, and imaging techniques we dissect these complex behaviors in mammals.
We use two functional genomics approaches in mice – forward genetic ethylnitrosourea (ENU) mutagenesis screens and quantitative trait loci (QTL) analysis – to identify genes and pathways that regulate these behaviors. Powerful and unbiased, forward genetic approaches make no a priori assumptions and only require a clear well-defined assay for gene discovery. We have used high-throughput screening pipeline to discover mutants for cocaine response and open field behavior. Using physical mapping followed by next generation sequencing we have identified novel genes and alleles that regulate cocaine response and anxiety related behaviors.
Latest Lab News:
Very well written summary of our work in eLife. https://elifesciences.org/digests/63207/lights-camera-action
An updated version of Gait analysis paper is on Biorxiv. https://www.biorxiv.org/content/10.1101/2020.12.29.424780v2 It has new analysis from Keith Sheppard and Gautam Sabnis including several new figures in the supplement. We look forward to getting reviews...
Paper link is here https://elifesciences.org/articles/63207 Data associated with the paper is here with video data uploaded to Zenodo https://zenodo.org/record/4646088 We also share some videos of our network in action:...